Slaframine Toxicosis in Animals

Slaframine Toxicosis in Animals

Important Concepts

• Slaframine Toxicosis: Caused by ingestion of clover infected with Slafractonia leguminicola (black patch disease).

Infectious Agents

• Slafractonia leguminicola: Produces slaframine and potentially swainsonine.

Clinical Changes

• Signs: Profuse salivation, lacrimation, diarrhea, mild bloat, frequent urination.

• Sensitivity: Horses highly sensitive; cases also in cattle.

Pathological Changes

• Mechanism: Slaframine induces salivation and gastrointestinal disturbances.

Diagnosis

• Clinical Signs: Recognition of symptoms and black patch on forages.

• Confirmation: Chemical detection of slaframine in forages.

Treatment

• Immediate Action: Remove contaminated feed.

• Supportive Care: Atropine for salivary and GI signs.

For more details, visit the Merck Veterinary Manual on Slaframine Toxicosis.